בקרית ארבע. עַל שֵׁם אַרְבַּע עֲנָקִים שֶׁהָיוּ שָׁם, אֲחִימָן שֵׁשַׁי וְתַלְמַי וַאֲבִיהֶם. דָּ"אַ עַל שֵׁם אַרְבַּע זוּגוֹת שֶׁנִקְבְּרוּ שָׁם אִישׁ וְאִשְׁתּוֹ, אָדָם וְחַוָּה, אַבְרָהָם וְשָׂרָה, יִצְחָק וְרִבְקָה, יַעֲקֹב וְלֵאָה (בראשית רבה): בקרית ארבע literally, the city of the Four, and it was so called because of the four giants who lived there: Ahiman, Sheshai, Talmai and their father (Numbers 13:22). Another explanation is that it was so called because of the four couples who were buried there, man and wife — Adam and Eve, Abraham and Sarah, Isaac and Rebecca, Jacob and Leah (Genesis Rabbah 58:4).
ויבא אברהם. מִבְּאֵר שֶׁבַע: ויבא אברהם AND ABRAHAM CAME from Beer-Sheba
לספוד לשרה ולבכתה. וְנִסְמְכָה מִיתַת שָׂרָה לַעֲקֵדַת יִצְחָק לְפִי שֶׁעַל יְדֵי בְּשׂוֹרַת הָעֲקֵדָה, שֶׁנִּזְדַּמֵּן בְּנָהּ לִשְׁחִיטָה וְכִמְעַט שֶׁלֹּא נִשְׁחַט, פָּרְחָה נִשְׁמָתָהּ מִמֶּנָּה וּמֵתָה: לספוד לשרה ולבכותה TO BEWAIL SARAH AND TO WEEP FOR HER — The narrative of the death of Sarah follows immediately on that of the Binding of Isaac, because through the announcement of the Binding — that her son had been made ready for sacrifice and had almost been sacrificed — she received a great shock (literally, her soul flew from her) and she died (Pirkei DeRabbi Eliezer 32).